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In vitro biochemical analyses have shown that both monomeric and oligomeric -syn bind double-stranded DNA through electrostatic interactions, leading to conformational changes such as local bending, unwinding, or relaxation of supercoils ( Perspectives -synuclein and PARP-1 are both actively involved in the pathological process of PD, forming a self-perpetuating vicious cycle

ATF6 deficiency in microglia attenuates inflammation in autoimmune encephalomyelitis by promoting NF-B p65 degradation (202)

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Evidence indicates that the GM markedly elevates circulatory 25-hydroxyvitamin VitD levels by promoting the production of lactic acid and 7-dehydrocholesterol, therefore aiding skeletal calcium absorption (200)