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Concurrently, GSHa critical intracellular antioxidantbecomes depleted, compromising the cell's capacity to neutralize ROS and lipid peroxidation products, thereby accelerating ferroptotic progression (21)

In short-term trials, particularly those involving HIV patients experiencing muscle wasting, the hormone has been administered in doses up to 0.1mg per kg of body weight for up to three months

The PUFA composition also impacts neuroinflammation by regulating cytokine secretion, particularly interleukins IL-4, IL-10, IL-17, and TNF- [15]

Due to its molecular structure, however, it is sensitive to enzymatic degradation conventional glutathione therefore often fails to fully reach the target structures in the body