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A multicenter, double blind RCT that included 332 patients with inflammatory acne demonstrated that minocycline hydrochloride treatment was superior to oral zinc gluconate regarding improvement in superficial inflammatory count and comedone count after three months of use

Future clinical studies should account for baseline choline status, microbiome profiles, genetic polymorphism in choline metabolic pathways, and organ-specific outcomes to define optimal strategies for leveraging the use of modulating choline availability and metabolism in personalized therapeutic interventions

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