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Previous data have demonstrated the vital role of probiotics in a variety of chronic conditions such as diabetes, cancer, hypertension, inflammatory disorders, immune disorders, respiratory diseases, GIT disorders, liver disorders, allergy, and a variety of infections (Iqbal et al., 2014

In the acidic environment (low pH), the antioxidant (cytoprotective) activity of nanoceria is lost, and it acts as a prooxidant which causes oxidative stress by producing ROS and thus induces cell death/apoptosis [25]

Further studies with the longer duration of ALCAR administration are necessary to adequately assess the efficacy of ALCAR following pediatric TBI

Modifications such as the substitution of tyrosine at the N-terminus appear to improve its stability compared to the native sequence