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Human ApoE, particularly in brain tissue and CSF, is highly glycosylated, and the glycan chains are exclusively attached via an O -linkage to Ser or Thr residues

One suggestion of the metabolic substrate these cells can provide comes from the lactate shuttle hypothesis, which proposes that glial cells like astrocytes and Mller glia can uptake glucose and convert it to lactate to provide a metabolic substrate to RGCs (Hurley et al., 2015)

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Manjon C, Troczka BJ, Zaworra M, Beadle K, Randall E, Hertlein G, Singh KS, Zimmer CT, Homem RA, Lueke B, Reid R, Kor L, Kohler M, Benting J, Williamson MS, Davies TGE, Field LM, Bass C, Nauen R (2018) Unravelling the molecular determinants of bee sensitivity to neonicotinoid insecticides