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[] The Cardiac Rehabilitation Outcome Study in Heart Failure (CROS-HF) study did not show a clear improvement in either mortality or hospitalization, it confirms the improvement in exercise capacity and health-related quality of life with participation in exercise-based cardiac rehabilitation

Its low skin permeability (Log Kp = 8.81 cm/s) reflects restricted passive diffusion across lipid membranes, consistent with its hydrophilic character