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In the absence of reduced glutathione (e.g., due to G6PD deficiency), RBCs become susceptible to oxidative stress that can damage erythrocyte membranes, resulting in intravascular and extravascular hemolysis

Dogra S, Singh N, Kumar S, Narang T, Handa S (2022) Comparison of overall efficacy and safety of oral versus subcutaneous methotrexate in severe psoriasis