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There has even been speculation that people who naturally produce less NAD+ may be more likely to develop substance abuse disorders

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This negative trial ended clinical development

Furthermore, this trend toward increased alpha diversity in the obese groups placed on an LD that had consequently experienced weight loss aligns with clinical observations, where low gene richness has been associated with increased adiposity, insulin resistance, and dyslipidemia 70 while increased gene richness has been observed following dietary intervention in obese and overweight individuals 71