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The enzyme is inactivated upon oxidation of its iron-sulfur cluster by superoxide [35]

10.1.3.3 Summary of the results of risk assessment TDI Oral studies 1.42 g/kg body weight 1.72 g/kg body weight TC TDI (calculated from the TC) Inhalation studies 6.1 g/m 3 0.85 g/kg body weight 6.7 g/m 3 0.92 g/kg body weight 11.4 g/m 3 1.56 g/kg body weight 10.1.3.4 Conclusions based on exposure and health risk assessment On the basis of exposure data presented in chapter 5, an approximate upper-limit estimate of the daily intake of carbon tetrachloride for long-term exposure of the general population can be made for prevailing normal exposure and for a "worst case scenario"

The blend is processed using standard 0.22-micron sterile filtration techniques and filled aseptically under strict sterile environments to minimize particulate and microbial presence during baseline testing

Statistics All data were analyzed in R as described in each relevant section of the Methods and figure legends