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Description

Deficient glutamate clearance, usually associated with downregulation of EAAT transporters is one of the primary mechanisms of glutamate excitotoxicity leading to neuronal death (see Table 2 and the previous section)

10.1021/acssynbio.1c00514

It reduces oxidative stress proteins, p38 mitogen-activated protein kinase (p38 MAPK) and glial fibrillary acidic protein (GFAP) activity in the morphine-induced neuroinflammation model of rats (35)