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Deamidation breaks the backbone Asparagine and glutamine residues in the tirzepatide sequence are vulnerable to deamidation, a chemical reaction where the amide group converts to a carboxylic acid

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, proliferative vitreoretinopathy, stage c-1 or greater, diabetic traction retinal detachment, retinopathy of prematurity, retinal tear of greater than 90 degrees), with vitrectomy and membrane peeling, including, when performed, air, gas, or silicone oil tamponade, cryotherapy, endolaser photocoagulation, drainage of subretinal fluid, scleral buckling, and/or removal of lens))

Fourteen patients (89%) had previously had a PR to daratumumab