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(1977) after Wolf et al

There are three extra cysteine residues in the Trx1 structure, reported to be easily oxidized and implicated in the formation of molecular aggregates or oligomers and inactivation of the enzyme

10.1016/j.lfs.2020.117581 181 MakvandiP.AliG

APAP is metabolized to a toxic metabolite called N-acetyl-p-benzoquinone imine (NAPQI) that begins to accumulate in the cell, leading to mitochondrial dysregulation [15]