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Future progress will likely require broader target diversification beyond dopamine-centered strategies, together with rigorous evaluation of long-term safety, brain distribution, cognitive outcomes, and clinical applicability in biologically relevant models

The complication is that low B12 in cats is often linked to absorption problems from gastrointestinal disease, meaning adequate intake may still not translate into adequate blood levels

Candidate bioactive species can be introduced into ML cell lines and one can screen for bioactive species which alter the intracellular processing of foreign bioactive species and sequence of the foreign peptide that is presented to T cells by MLs on their cell surface in the context of Class II MHC