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The H 2 O 2 molecule closest to the active site oxidises the resting enzyme to Compound 1, and is itself reduced to water

However, there are multiple pathways that result in upregulation of COX-2 in brain neurons, including increased N-methyl-D-Aspartate (NMDA) receptor-dependent activity (230), cerebral ischemia, seizures, and diseases such as AD or PD (231)

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First, our study was a single-arm study without a control group