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Pioglitazone inhibits mitochondrial pyruvate metabolism and glucose production in hepatocytes

These mutations lead to constitutive activation of Ras, resulting in persistent activation of the MAPK pathway, promoting uncontrolled cell proliferation and survival

These two death pathways collectively exacerbate ROS bursts, with particularly significant effects on tumors dependent on antioxidant defense mechanisms (such as high SLC7A11 expression or KRAS mutations) (Li H

The most challenging period for patients is the initial phase of diet implementation, during which hypoglycemia, dehydration, and GI disturbances are most common [201, 202]