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Description

GGAUGGAUGCCUGCUUUUUtt, antisense

Targeting KAT2A could provide a new strategy to block MYCNs oncogenic activity in neuroblastoma

This generally agrees with the flood-gate model of ROS dynamics 70,71 , where a prolonged ROS stimulus (e.g., rotenone) can be cleared over time, but a sudden larger insult of ROS (e.g., pulsed KR stimulation) overwhelms redox machinery and leads to diffusion between compartments and ROS release into the cytosol