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3 Mitophagy signaling pathways 3.1 PINK1-parkin-dependent mitophagy In 1998, Lemasters and colleagues observed that under nutrient-deprived conditions, a portion of mitochondria underwent spontaneous depolarization and were subsequently engulfed by lysosomes

Whereas there has been a significant improvement in our understanding of the mechanism that underpin the primary and secondary stages of damage associated with a TBI incident, to date however, this knowledge has not translated into the development of effective new pharmacological TBI treatment strategies

Conclusion The BPC-157 / TB-500 peptide blend presents a fertile and largely uncharted frontier in regenerative research

Annu Rev Pharmacol Toxicol 56:361383