The three mutants that were identified are deletion strains of the transcription factor YAP1 , and two strains deleted for genes that encode enzymes involved in the synthesis of phosphatidylcholine, namely CHO2 and OPI3
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After 4 half-lives the drug accumulation will be close to steady state
Disclosures: Moony Su: Nothing to Disclose, Olivia Matthews: Resolution Therapeutics: Employee, Resolution Therapeutics: Stock privately held company, Mark Cant: Nothing to Disclose, Anna Hoy: Resolution Therapeutics: Employee, Resolution Therapeutics: Employee, Resolution Therapeutics: Stock privately held company, Niya Aleksieva: Nothing to Disclose, Rachel Lopera: Nothing to Disclose, Philip Starkey Lewis: Resolution Therapeutics Ltd: Employee, Resolution Therapeutics Ltd: Stock privately held company, Alejandro Armesilla-Diaz: Nothing to Disclose, Keith Sutton: Resolution Therapeutics: Employee, Kayleigh Thirlwell: Nothing to Disclose, Lara Campana: Resolution Therapeutics: Employee 1991 HEPATIC STELLATE CELLS FACILITATES AMMONIA DETOXIFICATION THROUGH GPT1-MEDIATED ALANINE SYNTHESIS IN HEPATOCELLULAR CARCINOMA Thi Nga Ha 1 Hyon-Seung Yi 1 Dong Wook Choi 2 , 1 Chungnam National University, 2 Korea University Background: Targeting metabolic reprogramming during the activation of hepatic stellate cells (HSCs) has recently been highlighted as an emerging strategy for mitigating hepatic diseases
