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For more information on Ankylosing Spondylitis , visit the Arthritis Foundation at www.arthritis.org or the Spondylitis Association of America at www.spondylitis.org

Activated PERK inhibits global translation by phosphorylating eukaryotic translational initiation factor 2 alpha (elF2), resulting in promoting the restoration of ER homeostasis (42)

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Role of BMAL1 in macrophages The activity of macrophages exhibits a distinct circadian rhythm, and approximately 8%-15% of genes in macrophages display circadian oscillations