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The loss of this ferroptosis suppressor, together with the dysregulation of other antioxidant pathways, such as NRF2 signaling and glutathione synthesis, creates high susceptibility to iron-mediated lipid peroxidation in ALS neurons [235]

Based on the aforementioned pathological characteristics, this review will systematically assess the advantages and disadvantages of the existing methods for preparing GA animal models and evaluate their capabilities and values in simulating specific pathological processes

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19 Individuals with pre-existing kidney disease should avoid high dose glutathione