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Fatty acids and their metabolites can control protein expression involved in lipid and energy metabolism by influencing gene transcription, mRNA processing, and posttranslational modifications [118, 119, 120, 121]

This is because lots of supplements contain metals like zinc, copper, and chromium, which have been known to cause this unpleasant side effect, according to Cleveland Clinic

[1] The formulation delivers 17-estradiol in a depot that slowly releases hormone over several weeks, thereby potentially supporting more stable serum estrogen concentrations than daily oral or transdermal preparations and potentially improving symptom control for individuals with hypoestrogenism or menopausal vasomotor instability

The above DEGs were also related to oxidative stress (Hmgcs2, Drd5, and Slc4a11) (Fig