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On the other hand, nuclear factor-kappa B (NF-B) is a transcription factor that promotes the expression of pro-inflammatory cytokines and related enzymes such as cyclooxygenase, inducible nitric oxide synthase and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Patel et al., 2017)

B12 is an essential nutrient, and its deficiency is common, especially among individuals following restricted diets like vegetarianism or veganism, pregnant or breastfeeding women, older adults, those who have undergone gastrointestinal surgery or have gastrointestinal disorders, and people with an autoimmune condition known as pernicious anaemia

Need for maintenance dose: Need Of Maintenance Dose-Picture Courtesy: Health Cleveland Clinic Initially you administer dose every week for almost 6 weeks

The digestive tract is bypassed entirely, meaning nutrients reach target tissues in concentrations that oral vitamins rarely match