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(Native, unmodified recombinant human IGF-1, sold as mecasermin/Increlex, is FDA-approved only for a narrow pediatric growth-failure indication and is chemically distinct from the LR3 analog.) In the US it is manufactured and sold almost exclusively as an unregulated "research chemical" labeled "not for human consumption," a labeling practice peptide vendors use to avoid marketing it as an unapproved drug

To answer that, it helps to understand how these two companies operated and what made them popular in the first place

The human evidence is far thinner: three studies exist, two in inflammatory bowel disease (oral formulation) and one in distal radial fracture healing, none of them controlled trials

Its important that a skilled dermatologist or plastic surgeon performs these, as the eye area must be handled very carefully