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It is best to avoid using non-metabolizable nanoparticles in lung tissue while designing nanoparticles [116, 117]

doi: 10.1155/2019/4574276

Monitoring PpIX biosynthesis in vivo by real-time FL/PA duplex imaging As oxidative stress is a key to the synergistic effect of IIT and 5-ALA-PDT for enhanced therapeutic efficacy 37,47,48 , we explored the metabolic dynamics of PpIX and O 2 generation to validate the feasibility for PpIX synthesis regulation and optimizing treatment parameters in vivo

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