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These data indicate that dHTC1 afforded a probe with more suitable properties for experimentation in vivo compared to a similarly unoptimized PROTAC

Skipsey et al., 2011)

Three distinctive cellular protective mechanisms against ferroptosis Studies have hitherto demonstrated that cells may have evolved at least three defense systems with different subcellular localizations, of which cytosol- and mitochondria-localized GPx4 confers the major protection against lipid peroxidation, while ferroptosis suppressor protein 1 (FSP1) acts mainly on the plasma membrane, and dihydroorotate dehydrogenase (DHODH) is a major defensive arm in mitochondria

PMID: 97 MartemucciG.FracchiollaG.MuragliaM.TardugnoR.DibenedettoR