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Moreover, ferroptosis, which occurs in tumor cells, can spread to neighboring cells via the paracrine release of lipid peroxides (Nishizawa 2021)

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10.3168/jds.S0022-0302(89)79318-8

Histone Kla is significantly increased on the promoters of M2-like genes in the later stage of stimulated M1 macrophage polarization, suggesting that histone Kla probably acts as a lactate clock to promote the switch from an inflammatory phenotype to a steady-state phenotype in macrophages