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In order to verify whether VD and thiols status are associated to the outcome of COVID-19 disease, we conducted a multicenter retrospective study among both children and adult patients with COVID-19 admitted to our Institutions during the first wave of the Italian COVID-19 outbreak

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GABA is synthesized from the amino acid glutamate with the enzyme glutamate decarboxylase (GAD) and pyridoxal phosphate (which is the activated form of vitamin B6) as the key cofactor