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The nucleophilic attack initiated by GSH occurs either by a substitution (e.g., on a chlorine atom) or by the reduction of an electron acceptor via a Michaels addition (Deponte, 2013)

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For example, clinicians can recommend the use of curcumin mouthwash or gel for patients with gingivitis who seek herbal alternatives, or the use of curcumin gel as a postscaling medication in periodontal pockets to enhance healing