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Lipid and vitamin metabolism pathways, including thiamine, biotin and lipoic acid, were also downregulated in GLI, mirroring transcriptomic data (Loberman-Nachum et al, 2019)

This can lead to disturbances in energy metabolism, decreased mitochondrial membrane potential, and developmental arrest [210]

2g), which could be combined with the TEM images to indicate that NPC membrane of MBC had a good stability in the degenerative NP-mimic microenvironment during the primary periods (Supplementary Fig