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10.1111/j.1600-0625.2007.00613.x 228

Research utilizing National Health and Nutrition Examination Survey (NHANES) data revealed that after adjusting for confounding factors including sex, age, body mass index, and smoking status, a significant positive association persisted between constipation and major depressive disorder (MDD) [odds ratio (OR) = 2.42, 95% confidence interval (CI): 1.863.14] (Wang et al., 2023)