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FY25 inspection-based warning letters also surpassed the 111 inspection-based letters issued in FY24, 3 as well as the 94 inspection-based letters issued in FY23 4 and the 74 inspection-based letters issued in FY22

Furthermore, a subset of clinical investigations and animal trials have demonstrated that protracted recanalization therapy (lasting over 24 h or even approaching a month) confers benefits to patients, and the relevant mechanisms need further exploration [6, 7]