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Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

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1 Overview of Serpinb9 Serpinb9 (Sb9), first defined in 1995 ( Serpins exert their inhibitory effects on proteases, contributing to various physiological processes, including inflammation, complement activation, blood coagulation, tissue remodeling and immune response as well as prevention of inappropriate activity of cytotoxic proteases induced apoptosis ( All serpin proteins share a conserved tertiary structure characterized by a core domain with three sheets, eight-nine helices, and a flexible reactive center loop (RCL) that contains seventeen amino acids and is positioned in the protease recognition domain close to the Cterminus of serpin ( Sb9 is extensively expressed in both the cytoplasm and nuclei of various human endothelial, mesothelial and immune cells, particularly in immune-privileged sites such as placenta, testes, ovaries and eyes ( + T cells), as well as in antigen-presenting cells ( As previously noted, Sb9 is a potent physiological inhibitor of GzmB through formation of protein complex