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However, those pretreated with LA showed normal marker enzyme patterns and normal levels of reactive oxygen species and thiols

This dysfunction cascade further compromises cellular integrity and energy-dependent physiological functions such as ion channel activity and synaptic transmission [54, 55]

In summary, while prolonged UV-A exposure to mice in vivo induces a variety of cataract morphologies that differ to those observed in humans, these studies showed that elevated protein insolubility and impaired enzyme function are caused by UV-B irradiation