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And with the increased time of ethanol intake, more activated microglia were found, suggesting the continuous elevated oxidative stress and neuroinflammatory damage induced by ethanol exposure

Using a high-content phenotypic assay, researchers identified small molecules such as RH1115, which modulates autophagic flux by targeting proteins like Lamin A/C and LAMP1, promoting neuronal health and altering lysosome positioning for potential therapeutic benefit [140]

[Abstract]2026 Apr 24:361:121230

Similarly, in ovarian cancer cells, CBS inhibition resulted in mitochondrial dysfunction and ROS overproduction (Table 1), consistent with a malfunctioning mETC