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Nonetheless, the increased demand for energy and building blocks for macromolecule synthesis upon mTORC1 activation, together with the block in autophagy, results in a biosynthetic burden that the cell alleviates with the execution of parallel programs that reinforce nutrient uptake (Torrence et al., 2020) and synthesis (Valvezan et al., 2017), and also enables the catabolic capacity of the cells through the proteasomal degradation of proteins (Zhang et al., 2014) to remove unwanted cellular material and to boost the pool of free amino acids available for protein synthesis

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doi: 10.1038/srep34990 409 NiblettSHKingKEDunstanRHClifton-BlighPHoskinLARobertsTKet al

As was described in Section 3, most of the 4-aminoquinolines are usually more active against intracellular amastigotes than promastigotes or axenic amastigotes, which suggests that further experiments of these compounds, in particular, for compound 13 , are required to evaluate the real potential of the hybridized N -(2-(indol-3-yl)ethyl)-7-chloroquinolin-4-amines