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The inhibition peaked at 57% in the presence of 40 M simvastatin for both ADP- and FCCP-stimulated respiration

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However, given ethical concerns raised in the literature regarding giving MS patients intravenous placebo, for this initial study we opted to have a waitlist control to first see if there was a positive signal to advance to the next level of inquiry ( Finally, this is the first study to use FDG PET to evaluate the effects of an intervention in patients with MS

When combined with losartan, there is an increased risk of high potassium levels because of its effects on retaining potassium