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Grx2 contains the CSYC active site, allowing it to accept electrons from TrxR [28] and to form the dimeric Fe 2 S 2 -bridged holo-complex [21,29]

However, although some previous studies investigated the effect of the size of nanoparticles, such as liposomes, on this strategy 34 , the mechanism still needs to be clarified, especially in single to sub-hundred nanometer range