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Description

[PMC free article: PMC4459776] [PubMed: 20559296] 65

Intermediate users commonly use 300-400 mcg daily, while advanced protocols may utilize 500 mcg daily or divided doses of 250 mcg twice per day

The side effects are mild and temporary

These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance