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However, the difference was not statistically significant

78, 79 As NR4 subfamily nuclear receptors (e.g., Nur77, NURR1) are ubiquitous heterodimerization partners of RXR in forming heterodimers, 80 current study also revealed that when the cancer cells are incubated with HX600, a selective RXR agonist for Nur77-RXR and NURR1-RXR, the expression of CPTIA is induced through Nur77 or NURR1-mediated mechanism in the teratocarcinoma cells or heptoma carcinoma HepG2 cells 81 (Figure 3)

It occurs in the presence of poor aqueous tear flow, excessive tear evaporation, or a combination of these events, due to changes in tear composition and production [11]

Appropriate FAD-dependent enzyme activity is likewise essential for bloodbrain barrier integrity: deficits in flavin enzyme function compromise endothelial tight junctions, increasing barrier permeability and facilitating neuroinflammatory propagation