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Aug 2010;25(6):462-71

Thus the composition of the gut microbiome and the balance between TMA-producing taxa and others critically influence how much TMA is made from a given diet ( 3.2 Host hepatic oxidation: from TMA to TMAO Following intestinal absorption, TMA is rapidly oxidized in the liver by flavin monooxygenases (FMOs), specifically FMO1 and FMO3

George, A

Across the major clinical programs, most gastrointestinal events were described as mild to moderate in severity, and discontinuation rates were still an important part of how Tirzepatides overall profile was evaluated