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Interestingly, CBS is upregulated by transcription factors such as nuclear factor erythroid 2-related factor 2 (NRF2) 17 , SP1/3 18 , and NFY 18 and its upregulation confers resistance against ferroptosis in ovarian cancer cells 17

It has been observed that repeated doses of DCA resulted in loss of GSTZ1-1 protein and activity, probably due to post-translationally modifications of the enzyme 85

Collectively, our findings demonstrate that GGCT can coordinately regulate both Gln and Glc metabolism and drives cell proliferation via two distinct mechanisms

Although such research is limited, the overexpression of GPx1 in breast cancer is thought to promote the occurrence and development of breast cancer