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Mouse studies reported changes in liver fat, inflammation and histology

doi: 10.3322/caac.21834 2 SiegelRLMillerKDJemalA

The ferroptosis signalling pathway is comprehensive, and in addition to the classical disorders of iron metabolism, the glutathionecysteamineglutathione system and polyunsaturated fatty acid metabolism, an increasing number of signalling pathways, such as nicotinamide adenine dinucleotide phosphate/ferroptosis-inhibitory protein 1 and tetrahydrobiopterin/GPT cycloheximide 1/dihydrofolate reductase, have been identified 51

Metformin protects against neuroinflammation through integrated mechanisms of miR-141 and the NF-B-mediated inflammasome pathway in a diabetic mouse model