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Likewise, depletion of folliculin (FLCN), a component of the FNIP/FLCN GAP complex that promotes GDP-loading of RAGC (Lawrence et al, 2019), resulted in TFE3-L stabilization (Fig

The molecular mechanisms proposed to explain how ROS could specifically mediate brain damage are the following: (1) The lower levels of antioxidants can promote increased activity of lipoxygenase in CNS stimulating leukotriene production, thereby increasing the immunoinflammatory processes in the cerebral cortex

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Glutathione-responsive CD-MOFs co-loading honokiol and indocyanine green biomimetic active targeting to enhance photochemotherapy for breast cancer Yuanzhi He Jingwen Guo Huining Ding Min Lin Yihan Wu Zehui He Zhi Wang Qing Xia Chunyun Zhu Yongtai Zhang Nianping Feng Graphical abstract Abstract Breast cancer has now replaced lung cancer as the most prevalent malignant tumor worldwide, posing a serious health risk to women