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Possible explanations include: Placebo effect : Expecting increased energy may influence perceived alertness Correction of deficiency : People with B12 deficiency often experience fatigue and disrupted sleep patterns

The Hidden Costs of Low B12 For driven individuals focused on long-term goals, these "subtle" signs are a direct threat to healthspan

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In humans, two enzymatic reactions dependent on B12 are produced and activated in separate cellular compartments: methylcobalamin in the cytosol and adenosylcobalamin in the mitochondria (1)