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Inhibition of the LAT-1 transporter in the IMQ animal model did not suppress epidermal proliferation indicating the compensatory role for other transporters of the LAT family ( Cationic Amino Acid Transporter-1and -2 (CAT1 and CAT2), the main transporters of L-Arginine, are continuously expressed by keratinocytes, promoting the metabolism of L-arginine to nitric oxide (NO)

However, more research is needed to delineate how polyphenols and related metabolites, either phase II metabolites or those generated by the gut microbiota, might interact with systemic tissues, using in vitro and in vivo models [32]

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Additionally, the absence of cortisol elevation reduces glucocorticoid-driven catabolic interference, allowing structured evaluation of recovery-linked GH physiology while maintaining endocrine stability across experimental timelines