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It detects unmethylated CpG-DNA [45, 46] which triggers the MyD88-dependent signaling cascade, leading to the production of pro-inflammatory cytokines, such as Tumor Necrosis Factor (TNFa) and IL-6, through the activation of MAPKs and NF-kB [47]

[DOI] [PMC free article] [PubMed] [Google Scholar] Stavchansky VV, Yuzhakov VV, Botsina AY, Skvortsova VI, Bondurko LN, Tsyganova MG, Limborska SA, Myasoedov NF, Dergunova LV

Ligand preparation, docking grid generation and molecular docking PDB formatted six safener structures (Fenclorim, Benoxacor, Flurazole, Dichlormid, Oxabetrinil, Fluxofenim) were generated using CambridgeSoft ChemBioOffice Ultra 2010

Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline