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Clinical response rates in clinical trials have ranged from 30 to 60% over the first eight to 12 weeks, with endoscopic remission usually slower in onset

Oncogene 39(3):690702 Dilip A, Cheng G, Joseph J et al (2013) Mitochondria-targeted antioxidant and glycolysis inhibition: synergistic therapy in hepatocellular carcinoma

doi: 10.1038/s41568-019-0224-7 217 ZhangXZhangHLanHWuJXiaoY

The Caco-2 cells incubated with mitragynine at 0.1, 1, and 10 M for 72 h showed downregulation of mRNA and protein expression of the P-gp in a concentration-dependent manner ( Evidence of alteration of cellular barrier function by mitragynine in long-term exposure is concerning