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Lebedev et al., 2002

This can cause gigantism, or if excess secretion starts only in adulthood, a condition called acromegaly, which is characterized by enlargement of the bones of the face, hands and feet

S100A8/S100A9 also stimulates neutrophil microbicidal activity by induction of reactive oxygen accumulation, resulting in activation of NADPH-oxidase (113)