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For instance, immunosuppressive cell populations, such as M2-type macrophages, can protect tumor cells from the threat of ferroptosis by secreting antioxidants or directly blocking the ferroptosis signaling pathway ( 3.2 Biological functions of ferroptosis in tumor biology Ferroptosis, as a controlled cell death mechanism, has a prominent impact on the life cycle of digestive tract malignancies

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doi: 10.3389/fimmu.2025.1653378 Received 24 June 2025 Accepted 29 September 2025 Published 03 November 2025 Volume 16 - 2025 Edited by Jing Gao, National Engineering Research Center for Oil Tea, China Reviewed by Jhon Carlos Castao, University of Quindo, Colombia Md

So, as we rapidly approach a critical mass of people (not just Americans - China just approved its first GLP-1 drug for obesity) receiving these drugs, we have to consider something