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Rat plasma protein binding of kaempferol-3-O-rutinoside from Luan GuaPian tea and its anti-inflammatory mechanism for cardiovascular protection

20,104,105,106,107,108 GHR dysfunction clearly protects individuals with Laron Syndrome against aging-related diseases such as cancer and diabetes, but it is unclear whether GH/IGF1 deficiency increases human lifespan, although a handful of studies have indicated that attenuated GH/IGF1 function is associated with human longevity

However, in vivo use of free RES is limited by poor stability and low bioavailability

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